Relationship between Parental Head Circumference and Birth Type: A Pilot Study

1. INTRODUCTION

Obstructed labor means the lack of labor progression due to mechanical problems, such as a mismatch between fetal size, especially the fetal head, with the mother's pelvis or cephalo-pelvic disproportion (CPD), which can lead to stopping normal delivery and, ultimately, cesarean section [1, 2]. This disproportion can not only hurt the birth canal but also may lead to asphyxia and increase the chance of an infant's death [3]. Therefore, examination of the obstetric diameters is one of the vital parts of decision-making for the delivery type [4]. In other words, predicting this issue is vital in preserving the health of the mother and the infant [5]. On the other hand, the dimensions and weight of the infant also play a special role in passing through the birth canal and practically determining the birth type [6]. Because several factors affect the phenotype and weight of the newborn and consequently predict the birth type [7], examining the mother's pelvimetry alone cannot be a good indicator to determine the birth type [8].

Nowadays, anthropometric findings have a crucial role in understanding human development and a special effect on community health [9]. On the other hand, the genetics and phenotypes of each parent are closely related to the formation of neonatal phenotype during the embryonic period [10-12]. Some studies in recent years have shown that anthropometric indices of parents can be associated with fetal size, birth type, and complications of childbirth [13-16]. However, most studies have only studied maternal height and weight. For example, a very short maternal height (<150 cm) can be one of the causes of CPD [17] and has been reported as a risk factor in childbirth [18]. Also, maternal height and the outer pelvic width (distance between two greater trochanters) have been introduced as two predictors of CPD and increased risk of cesarean section [19]. However, conflicting reports have been specified about the effects of maternal height on neonatal weight. So, maternal height is not the only influential factor in infant phenotype, weight, and subsequent labor problems [20]. Although some maternal anthropometric data help determine and predict the birth type [21], few studies have been conducted on other anthropometric indices of the mother, such as head circumference (HC), pelvic circumference, and so on.

It seems that most studies have been conducted on mothers and few studies on fathers' anthropometric indices and the simultaneous effect of parental phenotypes on the birth type. For example, few studies on the father-baby relationship have shown that height and even father weight are vital factors in infant weight during birth [22, 23]. Although no relationship has been observed between the father's height and the risk of childbirth problems [15], it has been reported that a very tall father or a very short mother are both risk factors for high-risk childbirth [24]. More research is needed to investigate the father-baby relationships and genetic mechanisms that affect fetal growth [14].

As mentioned above, among a small number of anthropometric studies on parents of newborns, longitudinal variables, such as their height, have been investigated more, and no study has been done on transverse and circumferential parameters, such as HC and pelvic circumference and their relationships with birth type. One of the vital parameters in human anthropometry is HC in its largest part, which is usually measured in infants and children up to the age of 5 as part of routine child care in growth assessment to provide information about health, growth, and nutrition [25]. HC and height are higher in men than women, and a direct correlation is observed between them in the whole population [26].

Since nearly half of the genetic pool of the children belongs to the father, its epigenetics and phenotypes, such as height and HC, can be associated with the anthropometric coordinates of the newborn and, accordingly, the birth type and the risk of cesarean section (CS). In other words, a newborn that is a genetic product of the total outcome of the parent’s genome must cross the pelvic canal during delivery, whose dimensions are subject to maternal anthropometrics. In this pilot study, in addition to common metric and longitudinal anthropometric indices, such as parental height, other circumferential and transverse anthropometric indices of parents, such as HC, pelvic circumference and width, and their relationships with the birth type in the first pregnancy, have been studied. We also investigated the probability of presenting models in predicting the birth type.

2. MATERIALS AND METHODS

3. RESULTS

3.2. Descriptive Data of Anthropometric Variables in All Parents

Table 1 provides descriptive statistics of the entire anthropometric information on measured maternal and paternal parameters of the newborn. In the study of different anthropometric indices measured, in most cases, such as height, weight, HC, chest circumference, waist circumference, and foot length, the size of these traits in men or all fathers was greater than those in women or mothers (Table 1).

Table 1.

Trait	Paternal (Mean± SD)	Maternal (Mean± SD)
Age (year)	33.63 ± 4.78	31.12 ± 5.97
Height (cm)	177.60 ± 6.42	164.96 ± 4.90
Weight (kg)	82.33 ± 9.33	Before:64.09 ± 11.04 After:75.63 ± 12.41
BMI (kg/m2)	26.06 ± 4.37	Before:23.52 ± 3.91 After: 27.78 ± 4.37
Head Circumference (cm)	57.93 ± 1.76	55.87 ± 1.70
Chest Circumference (cm)	104.09 ± 7.54	98.54 ± 7.82
Pelvic Circumference (cm)	99.81 ± 8.00	101.24 ± 7.99
Pelvic Width (cm)	40.66 ± 6.03	38.57 ± 3.92
Wrist Circumference (cm)	18.51 ± 1.30	16.21 ± 0.89
Foot Length (cm)	26.84 ± 1.41	24.30 ± 1.38

Abbreviations: BMI= Body mass index, SD= Std. Deviation.

3.5. Comparing Parental Anthropometric Variables Based on the Birth Type

Table 4 presents the values of parents' anthropometric data by birth type. Different anthropometric parameters of the parents between the two groups of natural delivery and cesarean section, the father's HC, the mother's HC, and the mean of the parent's HC in the cesarean section group, were higher than those in the natural delivery group. Maternal weight at the end of pregnancy in the CS group was higher than that in the NVD group. The average weight gain of mothers during pregnancy in the CS group (14.30 ± 5.74 kg) was higher than the average weight gain of mothers during pregnancy in the NVD group (10.35 ± 3.75 kg) (P<0.05).

Table 4.

-	Birth Type	No	Mean± SD
Maternal age (year)	NVD		23	30.17 ± 5.98
-	CS		10	33.3 ± 5.63
Paternal age (year)	NVD		23	32.91 ± 5.43
-	CS		10	35.3 ± 2.21
Maternal height (cm)	NVD		23	164.47 ± 4.47
-	CS		10	166.1 ± 5.87
Paternal height (cm)	NVD		23	177.52 ± 6.67
-	CS		10	177.8 ± 6.14
Maternal weight Before (kg)	NVD		23	62.82 ± 10.66
-	CS		10	67 ± 11.94
Maternal weight After (kg)	NVD		23	73.17 ± 11.73
-	CS		10	81.3 ± 12.64
Paternal weight (kg)	NVD		23	82 ± 9.9
-	CS		10	83.1 ± 8.3
Maternal Head circumference (cm)	NVD		23	55.34 ± 1.55
-	CS		10	57.1 ± 1.44
Paternal Head circumference (cm)	NVD		23	57.47 ± 1.64
-	CS		10	59 ± 1.63
Maternal Chest circumference (cm)	NVD		23	97.08 ± 7.59
-	CS		10	101.9 ± 7.66
Paternal Chest circumference (cm)	NVD		23	103.78 ± 7.07
-	CS		10	104.8 ± 8.89
Maternal Pelvic circumference (cm)	NVD		23	101.08 ± 8.87
-	CS		10	101.6 ± 5.87
Paternal Pelvic circumference (cm)	NVD		23	99.82 ± 8.41
-	CS		10	99.8 ± 7.37
Maternal Pelvic Width (cm)	NVD		23	39.17 ± 3.93
-	CS		10	37.2 ± 3.7
Paternal Pelvic Width (cm)	NVD		23	40.95 ± 5.97
-	CS		10	40 ± 6.46
Maternal Wrist Circumference (cm)	NVD		23	16.21 ± 0.73
-	CS		10	16.2 ± 1.22
Paternal Wrist Circumference (cm)	NVD		23	18.39 ± 1.11
-	CS		10	18.8 ± 1.68
Maternal Foot Length (cm)	NVD		23	24.26 ± 1.38
-	CS		10	24.4 ± 1.42
Paternal Foot Length (cm)	NVD		23	26.78 ± 1.50
-	CS		10	27 ± 1.24
Paternal Height Difference (cm)	NVD		23	13.04 ± 7.15
-	CS		10	11.7 ± 5.96
Mean Parental Head Circumference (cm)	NVD		23	56.41 ± 1.1
-	CS		10	58.05 ± 1.06
Difference of MHC and MPW (cm)	NVD		23	16.17 ± 3.97
-	CS		10	19.9 ± 3.24
Difference of PHC and MPW (cm)	NVD		23	18.3 ± 4.17
-	CS		10	21.8 ± 3.88
MWD (kg)	NVD		23	10.34 ± 3.74
-	CS		10	14.3 ± 5.73

Note: MHC= Maternal head circumference, PHC= Paternal head circumference, MPW= Maternal pelvic width, MWD is Maternal weight differences. (= Maternal weight after- Maternal weight before), SD= Std. Deviation.

Comparing the proposed indices using the anthropometric measurements obtained from parents, such as the difference between the mother's HC size and the width of her pelvis, as well as the difference between the father's HC and the mother's pelvic width between the two groups, we found that these values were higher in the CS group than the NVD group, (Table 4 and Fig. 2).

Also, comparing anthropometric indices among naturally born infants and cesarean section, the difference was observed only in infants ‘foot length, which was higher in babies in the CS group,

4. DISCUSSION

The results of the current pilot study showed that the mean HC of the parents is a better index to predict the delivery type in the first delivery than other parental anthropometric parameters such as parental height difference [24] or maternal height [27]. According to some studies, the taller height of the mother has also reduced the risk of cesarean section, and the short height of the mother has increased the risk of cesarean section [28, 29]. In the present study, no relationship was observed between the height of the parents and the birth type and the increased risk of cesarean section. Although this relationship may be correlated in a larger population, the results of our pilot study showed that in the same population, the mean HC of parents is a better index to predict the delivery type. Our analysis showed that with each centimeter increase in the mean HC of the parent, the risk of cesarean section increases three times.

Comparing the anthropometric indices between men and women participating in this study regardless of their child’s birth type, showed that most of the measured parameters in men, except for the circumference and width of the pelvis, were more significant than those in women, which is consistent with the data obtained in previous studies [30-33].

In the present study on the relationships between the various parameters in men and women by gender, it was observed that the heights of men correlate with weight, pelvic width, wrist circumference, and foot length but are independent of the body's circumferential and transverse sizes, such as the HC, chest, and pelvis circumference. This means that men of the same height can have heads with different dimensions especially different HC, and these two anthropometric indices are not correlated tightly. Based on our findings, no correlation was seen between the sizes of the HC and any of the recorded sizes in men, which indicates that the size of the HC is almost independent of other anthropometric parameters. In men, the wrist circumference had a relationship with most other parameters. Nevertheless, this variable in women was only related to pelvic dimensions and weight. It can be said that due to the lack of pelvic changes for the preparation of childbirth in men, there is a synchronization in the growth of most parts of the body, especially in their length.

Overall, regardless of the birth type, it can be said that more correlation is observed between the demographic parameters in men than in women. For example, a correlation was observed between the chest circumference, the pelvic width, the wrist circumference, and even the fathers' weight with their height. However, no relationship was observed between any of the circumferential and longitudinal parameters of the mothers. Pelvic dimensions in women, although independent of height, were related to the mother's weight both before and at the end of pregnancy. This finding suggests that the circumferential parameters of the mother as an influential factor can be effective in the process of inheritance as well as in the birth type by forming different pelvic dimensions. It means that women of the same height have pelvises in different dimensions that may put some of them through a problem such as obstruction in the birth canal during labor. Unlike men, no relationship was observed between their height and weight (not before pregnancy and not after pregnancy) in women. The HC size of women, like men, was independent of most parameters but interestingly had a correlate with the weight at the end of pregnancy. Therefore, based on the results of this pilot study, it seems that the HC size in both men and women is independent of most longitudinal parameters.

As described above, no relationship was observed between the HC size of the fathers and mothers with their heights and their pelvic dimensions. However, the mother's weight at the end of pregnancy was a function of the HC size of the mother, and in mothers with cesarean delivery, the average HC size of the mother and the increased weight at the end of pregnancy was higher than the mothers with NVD. Consistent with our results, Whiter et al. showed that mothers with more increase in their weight during pregnancy have a higher risk of cesarean section [34]. Scott et al. also reported that the average weight of infants born with cesarean section is higher than that of infants born with normal delivery [35]. Whiter et al. also reported the average weight of infants more than 3500 g as a risk factor for cesarean section [34].

On the other hand, the mother's height will lead to more weight gain for the baby [36]. In a study, it was reported that the mother's HC was correlated to the fetal HC and the baby's weight, but the relationship of the mother's HC with the birth type had not been investigated [14]. However, Lipshoetz showed that the infant's HC is more important than the infant's weight in predicting cesarean section [37]. Therefore, it seems that the HC size of the mother, along with more weight gain at the end of pregnancy, will be accompanied by baby weight gain and size, which can be a factor in increasing the risk of cesarean section.

The size of the baby's head, like its other parts, is obviously affected by the epigenetics of the parents, and it can be indirectly related to the size of the parent's head [38]. In examining the anthropometric parameters of infants by gender and regardless of the birth type, it was observed that the average HC and weight of boys at birth is more than that of girls, similar to previous studies [15]. However, was observed between the pelvic dimensions of male and female infants, as well as their wrist circumference and foot length. Also, in this study, no relationship was observed between the baby's gender and the birth type. However, some previous studies showed that male babies are more exposed to the failure of delivery progression due to their heavier weight [39]. Of course, due to the multifactorial nature of the reasons for deciding to have a cesarean section and its relationship with gender [40], more studies on a larger population are needed in this issue. It should be mentioned that most couples referred to our center rejected participating in this study during the COVID-19 pandemic due to the extra time we asked them to stay in for further measurements. The HC size of babies delivered by cesarean compared to the NVD group was also larger, but this, which seems to be due to the small number of cases in this pilot study. However, although in the regression model, no correlation was observed between the parental anthropometric parameters and babies' phenotype, the average HC of parents in the cesarean delivery group was the probability of cesarean delivery.

CONCLUSION

It seems that the larger size of the mother's HC, considering its potential effect in increasing the mother's weight at the end of pregnancy along with an external factor, i.e., the paternal epigenetics (which can affect the different growth of the fetus and, consequently increase in the baby's weight and dimensions), and no relationship between the size of the mother's HC and her pelvic dimensions, can affect the risk of cesarean section. Also, in this pilot study, the average size of the parent's HC and the weight gain during pregnancy in the CS group was higher than in NVD, which confirms this hypothesis.

Therefore, an increase in the average size of the parent's HC, especially in couples in that the mother has a smaller pelvic width, can logically increase the risk of cesarean section by increasing the size of the baby, especially the baby's head. However, other factors, such as maternal nutrition, environment, underlying diseases, and so on, can effectively increase or reduce this risk, which requires further cohort studies. The limitation is that the study is a pilot study and had low participants because of the Coronavirus.

REFERENCES