Disability-adjusted Life Years of Hepatitis B in Iran during 2009–2019: An Analysis Based on the Global Burden of Disease Study 2019

Hepatitis B virus infection is currently among the ten leading causes of death from infectious diseases in the world. The aim of the current study is spatial analysis related to life years adjusted by hepatitis B disability in Iran from 2009 to 2019.

The study is ecological. Using data from the Global Burden of Diseases (GBD), cause-specific mortality served as the basis for estimating disability-adjusted life years (DALYs). Time trend analysis of DALYs attributed to hepatitis B from 2009 to 2019 and spatial pattern analysis and identification of high-risk and low-risk clusters of DALYs attributed to hepatitis B in Iranian provinces were performed. Time trend changes were evaluated using joinpoint regression analysis.

The most likely high-risk cluster with LLR=238.59 in the West of Iran includes the western provinces of the country (Lorestan, Kermanshah, Hamedan, Markazi, Khuzestan, and Ilam) (relative risk of occurrence 2.31). The three provinces of Lorestan (RR=2.22), Sistan and Baluchistan (RR=1.73), Golestan (RR=1.46) have the highest relative Khazar, and the three provinces of Gilan (RR=0.41), Mazandaran (CIR=0.48) and Kurdistan (CIR=0.51) had the lowest relative risk. During the years 2009 to 2019, the total DALYs decreased by 1.5% annually (p<0.05).

According to the results of the disease control and prevention programs, it can be effective in reducing the disease burden in the country by giving priority to the provinces that are among the high-risk disease clusters.