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CROSS SECTIONAL STUDY

A Cross-Sectional Study of the Impact of Knowledge, Medication Adherence, and Illness Acceptance on the Quality of Life in Hypertensive Patients

The Open Public Health Journal 21 Apr 2025 CROSS SECTIONAL STUDY DOI: 10.2174/0118749445383991250411050811

Abstract

Background

Hypertension is a major noncommunicable disease globally, affecting patients' quality of life due to changes in lifestyle and socio-psychological factors. Identifying key determinants of quality of life in hypertensive patients can aid targeted interventions.

Aim

This study aims to examine the impact of hypertension knowledge, medication adherence, and illness acceptance on the quality of life of hypertensive patients in Lhokseumawe, Aceh, Indonesia.

Methods

A cross-sectional study was conducted with 429 hypertensive patients using structured questionnaires. Data were analyzed using Structural Equation Modeling (SEM) with AMOS software version 22 to evaluate relationships among variables.

Results

Knowledge about hypertension (p < 0.001), medication adherence (p < 0.001), and illness acceptance (p = 0.003) significantly influenced quality of life, while demographic factors did not (p = 0.173). The model fit analysis confirmed the SEM model's adequacy.

Conclusions

Hypertension knowledge, medication adherence, and illness acceptance play critical roles in improving quality of life. These findings highlight the need for educational and emotional support interventions tailored to hypertensive patients.

Keywords: Hypertension , Quality of life, Structural equation modeling, Medication adherence, Illness acceptance.
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