RESEARCH ARTICLE


Nutritional Status of HIV Clients Receiving HAART: Its Implication on Occurrence of Opportunistic Infection



Sadikalmahdi Hussen1, *, Tefera Belachew2, Nezif Hussein3
1 Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia
2 Human Nutrition Department, Jimma University, Jimma, Ethiopia
3 Clinical Pharmacy Department, School of Pharmacy, Jimma University, Jimma, Ethiopia


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© 2017 Hussen et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia; Tel: 0911545735; E-mail: sadhussen@yahoo.com


Abstract

Purposes:

We aimed to assess the effects of nutritional status on occurrences of opportunistic infection in HIV/AIDS patients using antiretroviral therapy at Jimma University Specialized Hospital.

Methods:

We conducted a retrospective study on 340 adults who were taking antiretroviral therapy and the patients were followed for 2 years after they commence treatment. Medical Chart review was done from January 30 to February 28, 2014. SPSS for windows version 21 was used to analyze the data. The data was analyzed by SPSS for windows version 21.Time to occurrence of opportunistic infection was estimated by Kaplan-Meier analysis and Cox-proportional Hazard model was used to identify predictors of opportunistic infections.

Results:

Eighty three [24.4%] patients developed opportunistic infection after initiation of highly active anti-retroviral therapy. Fifty five [66.3%] patients were from malnourished group. Malnutrition, Stavudine based regimen, Zidovudine based regimen and taking isoniazid prophylaxis were associated with greater hazard of developing opportunistic infections.

Conclusions:

Malnutrition was significant predictor of opportunistic infections. Malnourished patients were associated with high risk and early development of opportunistic infections.

Keywords: Malnutrition, Opportunistic infections, Survival, Ethiopia.