Distribution of Voltage-gated Sodium Channel Mutations in Aedes Aegypti Populations from Rural Areas of Indonesia

The Open Public Health Journal 06 Oct 2023 RESEARCH ARTICLE DOI: 10.2174/0118749445255879231003110635



Semarang has been one of the endemic districts; since 2017, it has contributed to high dengue cases in Central Java. The study was conducted to see the mutation in the Voltage-Gated Sodium Channel (VGSC) Aedes aegypti genera.

Materials and Methods:

Aedes aegypti from 6 sub-districts in Semarang were examined, where each sub-district was taken from 2-3 villages endemic areas with high fogging intensity in Semarang. Ten larvae samples were taken from each village.

Results and Discussion:

The results showed that the resistant samples were 48.4% heterozygous and 51.6% homozygous resistant from Bawen, 100% heterozygous resistant from Bandungan, 73.3% heterozygous and 26.7% homozygous resistant from West Ungaran, 65% heterozygous and 35% homozygous resistant from Sumowono, 23.3% heterozygous and 66.7% homozygous resistant, and 10% still susceptible from Ambarawa, and 30% heterozygous and 70% homozygous resistant from East Ungaran districts.


Based on the results of the molecular test, the Ae. Aegypti in Semarang Regency has proven resistance to the pyrethroid insecticide cypermethrin.

Keywords: Cypermethrin Resistance, Mosquito, Vector, Aedes aegypti, Dengue Hemorrhagic Fever.
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