RESEARCH ARTICLE


Evaluation of Family Caregiver Burden among COVID-19 Patients



Abasat Mirzaei1, 2, *, Rasoul Raesi3, 4, Sam Saghari4, Mehdi Raei5
1 Department of Health Care Management,Faculty of Health, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2 Health Economic Policy Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
3 22 Bahman Khaf Hospital, Mashhad University of MedicalSciences, Mashhad, Iran
4 Department of Health Services Management, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
5 Health Research Center, Life Style Institute,Baqiyatallah University of Medical Sciences, Tehran, Iran


Article Metrics

CrossRef Citations:
24
Total Statistics:

Full-Text HTML Views: 1409
Abstract HTML Views: 1165
PDF Downloads: 457
ePub Downloads: 136
Total Views/Downloads: 3167
Unique Statistics:

Full-Text HTML Views: 751
Abstract HTML Views: 718
PDF Downloads: 351
ePub Downloads: 112
Total Views/Downloads: 1932



Creative Commons License
© 2020 Mirzaei et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at Health Economic Policy Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; E-mail: amacademic@yahoo.com


Abstract

Background:

Coronaviruses are a large group of viruses from the Coronaviridae family. Not only do the coronaviruses disrupt patients' lives, but they also affect caregivers. This study aimed to assess the burden of family caregivers of COVID-19 patients discharged from a hospital in eastern Iran.

Materials and Methods:

A descriptive cross-sectional study was conducted with 210 family caregivers of COVID-19 inpatients and outpatients. A total of 210 COVID-19 patients referred to 22nd-Bahman Hospital of Khaf from March 2020 to June 2020 were selected via simple randomization. Data were collected using the Zarit caregiver burden scale and a demographics form.

Results:

The care burden scores were 83.2% and 80.9% in the family caregivers of inpatients and outpatients, respectively, indicating the severity of care burden for COVID-19 patients. The mean scores of objective, subjective, and subjective-objective caregiver burden were significantly higher in male family caregivers and caregivers of inpatients than in female caregivers and caregivers of outpatients [p <0.01].

Conclusion:

The high objective, subjective, and subjective-objective caregiver burden in family caregivers is an alarm for mental health policy-makers. Therefore, healthcare managers need to consider plans and measures to reduce the care burden of family caregivers of COVID-19 patients.

Keywords: Care burden, Family caregivers, Patient, COVID-19, Health care, Policy makers.



1. INTRODUCTION

Coronaviruses constitute many viruses from the Coronaviridae family and include the common cold virus to more serious diseases such as SARS, MERS, and COVID-19. Coronaviruses were discovered in 1965 and have continued to be studied until the mid-1980s. The virus exists naturally in mammals and birds, yet seven human-transmitted coronaviruses have been identified so far [1]. The latest species, COVID-19, became widespread in December 2019 in Wuhan, China. The first case of the virus in Iran was reported in early March 2020 and has, ever since, affected all the provinces and cities. The World Health Organization has recently declared the disease a pandemic. All countries are taking similar measures to combat the disease, depending on the political, sociocultural, and healthcare system and the economic conditions of the respective country. With many possibly unknown dimensions, the disease has shocked families, socioeconomic agencies, and large economies of the world. Hence, all nations must cooperate with their governments to overcome the damage caused by the disease in the shortest possible time and with the lower number of casualties [2].

The sudden onset of the disease can have profound effects on one’s mental health. The more widespread the prevalence of the disease, the more substantial its impacts on society. The spread of an epidemy causes fear, and the fear may continue even after the disease has been eradicated. Improper control of a coronavirus may result in high prevalence, large-scale hospitalization, and poor quality of life of the affected individuals. A coronavirus disease and its complications impose economic burdens and reduce the psychological wellbeing of individuals. The disease can disrupt the patient’s social and familial relationships. Not only it disrupts the lives of patients but it also affects the caregivers [3].

Caregivers are individuals who are most involved in a patient’s care provision and his/her adaptation and disease control during the course of an illness and its treatment. Studies indicate that caregivers' quality of life is affected during the treatment course of a patient. When a person is inflicted with the COVID-19, his/her family members, spouse, friends, and colleagues are also affected. Fear of the disease and its impacts, feelings of helplessness, ambiguity about the future, anxiety, sadness, anger, grieving reactions, economic worries, psychological stress in interpersonal relationships, and fear of death are among the major psychosocial stresses during COVID-19. The process of transferring care provision from the hospital setting to home imposes a care burden to the family [4]. A patient’s care has an objective dimension and a subjective dimension: Objective care can be considered in terms of the time and finance devoted to caring, including financial, familial, and social expenses. Subjective care burden denotes the caregiver perception of the care burden, which includes mental, emotional, and behavioral problems caused by the disease.

Since around 20 years ago, new indicators called the burden of disease indicators were introduced to address the three issues of mortality, morbidity, and quality of life [5]. A disease burden is an indicator that includes the most important causes of disability and death. Therefore, it is a highly valuable indicator of operational and interventional planning. The disease burden provides the most important and objective part of needs-assessment and evidence-based policy-making [6]. This study aimed to evaluate the care burden of family caregivers of COVID-19 patients discharged from 22nd-Bahman Hospital in the city of Khaf, eastern Iran.

2.. METHODOLOGY

2.1. Materials and Methods

This is a descriptive cross-sectional study, which was conducted from March 2020 to June 2020. Given that the number of individuals in the population (patients) during this period was known and the total number of inpatients and outpatients amounted to 465, the Cochran's formula was used to estimate the sample size as n = 210. This calculation was made with an error rate of 5%. The main formula for calculating the sample size is as follows:

A total of 210 family caregivers of COVID-19 inpatients and outpatients discharged from the 22nd-Bahman Hospital of Khaf city, Iran, were selected by simple randomization. Inclusion criteria comprised a lack of mental problems in primary caregivers, the ability to read and write, a minimum age of 18 years, and a willingness to participate in the study.

At first, the purpose of the study was explained to the caregivers of the patients. Subsequently, they completed a demographics form. The researcher completed the Zarit caregiver burden scale one week after the patient was discharged through a phone call with the caregiver.

The caregiver burden scale was developed by Zarit et al. [1998] to measure the caregiver burden. The scale includes 22 items on personal, social, emotional, and economic pressures. The tool categorizes a caregiver’s experienced pressures into objective and subjective types. Objective burden refers to the negative effects of the disease on the primary caregiver and involves disruption of family relationships; restrictions on social activities, work and leisure; and physical and financial problems. Subjective burden refers to a caregiver’s emotional reactions to the patient, including mental stress, feelings of loss, and regret. According to this classification, in the Zarit caregiver burden scale, three items [i.e., 2, 3, 15] assess the objective burden, three items [i.e., 7, 8, 14] examine the subjective caregiver burden, and item 22 examines the subjective-objective burden.

2.2. Scoring and Interpretation

This questionnaire is based on a five-point Likert scale, with 0 = Never, 1 = Rarely, 2 = Sometimes, 3 = Often, and 4 = Always. To calculate the total score of the scale, the scores of all items are summed up, which can range from 0 to 88. A smaller score indicates a lower burden. The sum of the scores obtained by each caregiver denotes the caregiver’s burden. Scores 0 to 20 indicate low or no caregiver burden, scores 21 to 40 indicate moderate caregiver burden, and scores 41 to 88 indicate severe caregiver burden.

Desirable content validity has been reported for the scale items in the literature. In terms of CVI, a score range from 0.7 to 1 has been reported, which suggests the appropriateness of the scale in terms of the simplicity, relevance, and clarity of the items. The intraclass correlation coefficient [ICC] has been reported as 0.958, and the internal consistency of the instrument has been confirmed by determining the Cronbach’s alpha coefficient of 0.86 [7].

As this scale has not been used in the context of the COVID-19 disease, the validity of the instrument was assured by assessing its content validity through the opinions of 6 experts and specialists. For reliability purposes, a pilot study was performed with 30 people who had similar characteristics to the research population. The scale was completed by them twice within 10 days. The test-retest reliability of the tool and Cronbach’s alpha coefficient were calculated, indicating a correlation coefficient of 0.92.

The data were analyzed in the SPSS-16 statistical software using the Pearson correlation coefficient and Chi-square tests. The study protocol was approved by the ethics committee of Tehran Islamic Azad University of Medical Sciences (identifier: ID IR.IAU.PS.REC.1399.069).

3. RESULTS

Comparison of demographic characteristics showed that the inpatient and outpatient groups did not differ significantly in terms of gender, age, marital status, educational level, and occupation [p <0.05] (Table 1).

Table 1. Comparison of demographic characteristics of inpatient and outpatient groups
Variables Group Inpatient Outpatient P-Value
Number [percent] Number [percent]
Gender Male 56[58.9] 68[59.1] 0.98
Female 39[41.1] 47[40.9]
Age [year] ≥40 24[25.3] 29[25.2] 0.80
41-60 40[42.1] 53[46.1]
<60 31[32.6] 33[28.7]
Marital status Single 8[8.4] 12[10.4] 0.62
Married 87[73.6] 103[89.6]
Educational level Illiterate 50[52.6] 61[53] 0.99
Elementary 12[12.6] 15 [13]
High school 20[21.1] 23 [20]
Tertiary 13[13.7] 16[13.9]
Occupation Unemployed 16[16.8] 21[18.3] 0.97
Employee 14[14.7] 17[14.8]
Housewife 34[35.8] 36[31.3]
Self-employed 30[31.6] 40[34.8]
Student 1[1.1] 1[0.9]

Most of the family caregivers of inpatients were male [60%], while those of outpatients were female [73%] [p <0.001]. There was no significant difference between family caregivers in the two groups in terms of age, relationship with the patient, level of education, and occupation [p> 0.05] (Table 2).

The results showed that the frequency distribution of care burden in family caregivers of inpatients and outpatients was not significantly different [p = 0.28] (Table 3).

The results showed that the mean score of care burden in the family caregivers did not differ significantly in terms of gender, age, level of education, and occupation [p> 0.05] (Table 4).

The results showed that the mean score of objective, subjective, and subjective-objective caregiver burden in male family caregivers was significantly higher than those of female counterparts [p <0.01]. However, the mean scores of the total caregiver burden were not significantly different in male and female family caregivers [p = 0.85]. The mean score of total caregiver burden and its components did not differ significantly in the studied family caregivers regarding age, education level, and occupation [p> 0.05] (Table 5).

The results showed that the mean scores of objective, subjective, and objective-subjective caregiver burden in family caregivers of inpatients were significantly higher than those of outpatient family caregivers [p <0.001] (Table 6).

Table 2. Comparison of demographic characteristics of family caregivers of inpatients and outpatients
Variables Group Inpatient Outpatient P-Value
Number [percent] Number [percent]
Gender Male 57[60] 31 [27] <0.001
Female 38[40] 84[73]
Age [year] ≥30 19 [20] 18[15.7] 0.86
31-40 44[46.3] 57[49.6]
41-50 20[21.1] 24[20.9]
>50 12[12.6] 16[13.9]
Relationship with the patient Daughter 24[25.3] 30[26.1] 0.96
Spouse 59[62.1] 72[62.6]
Son 12[12.6] 13[11.3]
Educational level Elementary 32[33.7] 42[36.5] 0.87
High school 24[25.3] 26[22.6]
Bachelor's degree and higher 39[41.1] 47[40.9]
Occupation Employee 29[30.5] 34[29.6] 0.96
Housewife 46[48.4] 58[50.4]
Self-employed 20[21.1] 23 [20]
Table 3. Comparison of the frequency distribution of family caregivers’ burden in inpatient and outpatient groups
Group Mild Moderate Severe P-value
Inpatients 0[0] 16[16.8] 79[83.2] 0.28
Outpatients 3[2.6] 19[16.5] 93[80.9]
Total 3[1.4] 35[16.7] 172[81.9]
Table 4. Comparison of the mean score of care burden in the family caregivers according to demographic characteristics
Variable Group Caregiver’s burden score P-Value
Mean±SD
Gender Male 53.03±13.09 0.85
Female 53.39±14.13
Age [year] ≤30 53.46±14.62 0.82
31-40 53.72±13.85
41-50 53.41±12.28
>50 50.96±14.32
Educational level Elementary 52.93±14.22 0.97
High school 53.44±15.63
Bachelor's degree and higher 53.40±12.04
Occupation Employee 53.1±13.62 0.34
Housewife 54.37±13.99
Free 50.74±12.90
Table 5. Comparison of the mean score of total caregiver burden and its components in the studied family caregivers according to demographic characteristics
Group
Variable
Objective caregiver burden Subjective caregiver burden Objective-subjective caregiver burden Total caregiver burden
Mean ± SD Mean ± SD Mean ± SD Mean ± SD
Gender Male 8/30±1/37 9/28±1/89 3/34±0/66 53/03±13/09
Female 7/57±1/25 8/27±1/78 3/11±0/65 53/39±14/13
p-value
[independent t-test]
< 0.001 < 0.001 < 0.01 0.85
Age
[year]
≤ 30 8/00±1/31 8/70±1/98 3/27±0/61 53/46±14/62
31 – 40 7/79±1/44 8/69±1/92 3/11±0/65 53/72±13/85
41 – 50 8/00±1/28 8/75±1/79 3/39±0/69 53/41±12/28
> 50 7/79±1/17 8/61±1/89 3/21±0/69 50/96±14/32
p-value [ANOVA] 0.75 0.99 0.12 0.82
Education Elementary 7/89±1/39 8/80±1/94 3/26±0/66 52/93±14/22
High-school 8/20±1/47 8/38±1/69 3/34±0/63 53/44±15/63
Tertiary 7/66±1/19 8/79±1/95 3/09±0/66 53/40±12/04
p-value [ANOVA] 0.08 0.40 0.08 0.97
Occupation Employee 7/79±1/18 8/70±1/91 3/16±0/63 53/10±13/62
Housewife 7/82±1/43 8/74±1/87 3/26±0/65 54/37±13/99
Self-employed 8/12±1/37 8/58±1/92 3/16±0/72 50/74±12/90
p-value [ANOVA] 0.41 0.90 0.55 0.34
Table 6. Comparison of the mean scores of objective, subjective, and objective-subjective caregiver burden in inpatients and outpatients
Group
Caregiver burden
Inpatients Outpatients p-value [independent t-test]
Mean ± SD Mean ± SD Mean ± SD
Objective 8/82±1/20 7/09±0/86 < 0.001
Subjective 10/42±1/15 7/27±0/95 < 0.001
Objective-subjective 3/58±0/50 2/90±0/62 < 0.001

4. DISCUSSION

The current study results showed that the mean scores of objective, subjective, and subjective-objective caregiver burden were significantly higher in male than in female family caregivers. Moreover, male family caregivers endured a higher care burden in caring for inpatients, while females showed a higher burden in caring for outpatients. This issue is closely related to the Iranian socio-cultural circumstances, where the task of caring for children, the elderly, the disabled, and the sick are often infused with the housewives and girls. This care is considered as a part of housework. Given their major role in generating income and employment outside the home, men are not prepared to care for patients; besides, they fail to have sufficient time to play the caregiver role effectively [8]. Thus, men experience higher levels of objective, subjective, and objective-subjective caregiver burden when they act as family caregivers. Studies in Iran and other countries also show that women in most cases play the role of the primary caregiver at home [9-11]. This is probably why most of the family caregivers of outpatients in the present study were female. Family caregivers are often the parents, spouse, and other family members, who have the most contact with the patient in the treatment course and often experience emotional problems such as anxiety, depression, loneliness, frustration, anger, isolation, fear, and anxiety [12].

The study found that the mean scores of objective, subjective, and objective-subjective caregiver burden were significantly higher in family caregivers of inpatients than those of outpatients. Contributors to this can be the inpatients’ older age, the presence of underlying diseases, more intense care needs of these patients, and the poor prognosis. In their study, Tenforde et al. [2020] examined the characteristics of COVID-19 inpatients and outpatients, stating that the inpatients were typically older, had an underlying disease, more care needs, and a weaker prognosis. These findings have also been observed with influenza patients [13-16].

According to the results of the present study, the caregiver burden was severe in family caregivers, both of inpatients [83.2%] and outpatients [80.9%], with no significant difference between the groups. Also, the mean score of care burden in the studied family caregivers did not differ significantly in terms of gender, age, educational level, and occupation.

A search through available databases did not reveal a study examining the care burden in family caregivers of COVID-19 patients, although there were studies on the care burden of caregivers in other chronic diseases. Bamari et al. [2016] studied the primary caregiver’s burden of patients with type 2 diabetes, showing that the mean caregiver burden score was 38.85±11.91 [range: 6 - 77], which indicates moderate care burden [17]. Mollai et al.’s 2019 study reported a moderate care burden for most family caregivers [54%] of cancer patients [18]. Miguel et al. [2017] reported a moderate level of caregiving burden in caregivers of Portuguese patients with head, neck, cervical and rectal cancers [19]. Hosseini et al. [2014] concluded that most women caring for the elderly with Alzheimer's disease [62%] have a high care burden [20].

In the studies mentioned above, the level of care burden in most caregivers was moderate, while it is severe in the present study, which may be due to the novelty of COVID-19, limited information about the disease, its high prevalence, and unavailability of vaccines to treat it.

When a person is affected by COVID-19, his/her family members, spouse, friends, and colleagues are also affected by the caregiving burden. Fear of the infection and its complications, feelings of helplessness, ambiguity about the future, anxiety, sadness, anger, grieving reactions, economic concerns, and psychological stress in interpersonal relationships are some of the social-psychological tensions in the COVID-19 disease. Due to the increasing spread of COVID-19 and the shortage of hospital facilities and space for the care of these patients, the early discharge of COVID-19 patients from the hospital is on the rise. Therefore, most of the care is provided at home and family members take responsibility for care, whereas they have limited training and resources at hand [21]. As a result, the process of care transference from the hospital to home imposes a burden on the family. One of the reasons for the severe care burden in family caregivers of COVID-19 patients in this study is probably their lack of knowledge about the way to care for the patient.

In this regard, Ossee et al. [2006] stated that the lack of necessary information and specialized knowledge of family caregivers about their patients' illness and their health stands as a major problem for family caregivers [22]. Fulfillment of the informational needs of caregivers in the course of the disease and after its treatment can play an important role in increasing the physical and psychological capacity of caregivers [23, 24]. Although the Internet, especially social networks, has greatly enhanced information accessibility and dissemination, this platform has the potential to spread false information or fake news. Governments must guarantee the dissemination of accurate knowledge and clarify misinformation to help people deal with the COVID-19. If not, the rumors, false information, and the subsequent stress and anxiety among the patients will disrupt the process of health care provision [25].

Moreover, caregivers may suffer from socioeconomic problems that need special attention. They need to receive special attention and psychological support to cope with social problems. Studies indicate that caregivers, in addition to socioeconomic problems, may also have physical symptoms such as muscular pains and mental disorders such as stress, anxiety, or depressed mood [18, 21], all of which exacerbate the care burden for family caregivers.

As family caregivers are the key elements of home care provision, familial care and support can be seriously hampered if they have unsolved pressures and problems [26]. Accordingly, to adapt to the course of the disease, caregivers should be familiarized with the normal course of the disease. This way, they will have better adaptation, reduced fear of recurrence and the unknown disease, and higher tolerance of disease burden.

Therefore, it is necessary to design productive and informative training programs for home care providers of COVID-19 patients. Such programs can help caregivers increase their knowledge, enhance their management skills, and work more independently in care provision. Caregivers can envisage a better picture of the disease course [27]. Therefore, educational support given to caregivers can alleviate the suffering and burden caused by care provision. In most studies, educational programs have been considered for caregivers and families of chronic patients, which has led to improved care, lower psychological burden, and increased satisfaction of the caregiver [8]. In this regard, Navidian et al. [2019] conclude that family education has been effective in reducing the psychological burden in a sample of home caregivers and that this can, in turn, improve the quality of life of both the patient and his/her caregiver[s] [6].

Thus, this study suggests that appropriate programs be considered to support caregivers and that measures be taken to reduce the care burden of primary caregivers of COVID-19 patients.

CONCLUSION

The results showed that care burden was severe in family caregivers of COVID-19 inpatients and outpatients. The mean score of objective, subjective, and subjective-objective caregiver burden in male family caregivers is significantly higher than in female ones and the caregivers of inpatients than outpatients. The high level of care burden in the objective, subjective, and subjective-objective components is an alarm for mental health policy-makers to consider measures that can reduce the care burden of home caregivers. As a result, the consequences of care burden for family caregivers are reduced and caregivers can actively participate in caring for their family members, as part of community-based care. Also, according to local data collection, the results are not representative of the general community of patients with Covid-19 and the results of this article will not be able to generalize to all patients with Covid-19 in Iran and the world.

The results of the study showed that the burden of care in most family caregivers is severe for both inpatient (83.2%) and outpatient (80.9%) patients, which is in contrast to the care burden of most chronic diseases, which are usually moderate. This finding could be due to reasons such as the emergence of Covid-19, limited information about the disease, the high prevalence and lack of vaccines to treat it, and can be an important discovery and innovation in this study.

ETHICS APPROVAL AND CONSENT TO PARTICIPATE

The study protocol was approved by the ethics committee of Tehran Islamic Azad University of Medical Sciences, Iran (identifier: ID IR.IAU.PS.REC.1399.069).

HUMAN AND ANIMAL RIGHTS

Not applicable.

CONSENT FOR PUBLICATION

All patients participated on a voluntary basis and gave their informed consent.

AVAILABILITY OF DATA AND MATERIALS

The raw data and materials used to support the findings of this study are available from the corresponding author [A.M] upon request.

FUNDING

None.

CONFLICT OF INTEREST

The authors declare no conflict of interest, financial or otherwise.

ACKNOWLEDGEMENTS

We appreciate the Research Vice-chancellery of Islamic Azad University of Medical Sciences, Tehran Branch, which funded the project and the respectable authorities of 22nd-Bahman Hospital of Khaf city, Iran [affiliated with Mashhad University of Medical Sciences and Health Services]. Also, we do appreciate all family caregivers of patients in this study who helped us complete the study.

REFERENCES

[1] Weiss SR, Navas-Martin S. Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus. Microbiol Mol Biol Rev 2005; 69(4): 635-64.
[2] Tavakoli A, Vahdat K, Keshavarz M. Novel coronavirus disease 2019 [COVID-19]: An emerging infectious disease in the 21st century. ISMJ 2020; 22(6): 432-50.
[3] Arnout BA, Al-Dabbagh ZS, Al Eid NA, Al Eid MA, Al-Musaibeh SS, Al-Miqtiq MN, et al. The effects of corona virus [COVID-19] outbreak on the individuals’ mental health and on the decision makers: A comparative epidemiological study. Health Sciences 2020; 9(3): 26-47.
[4] Organization WH. Home care for patients with suspected novel coronavirus [‎ nCoV]‎‎‎‎ infection presenting with mild symptoms and management of contacts: interim guidance, 20 January 2020. Home care for patients with suspected novel coronavirus [‎‎‎‎‎‎‎‎‎‎ nCoV]‎‎‎‎‎‎‎‎‎‎ infection presenting with mild symptoms and management of contacts: interim guidance 2020; 2020
[5] Hiseman JP, Fackrell R. Caregiver burden and the nonmotor symptoms of Parkinson’s disease International Review of Neurobiology 133 2017; 479-97.
[6] Navidian A, Pahlavanzadeh S, Yazdani M. The effectiveness of family training on family caregivers of inpatients with mental disorders. Majallah-i Ravanpizishki va Ravanshinasi-i Balini-i Iran 2010; 16(2): 99-106.
[7] Bachner YG. Preliminary assessment of the psychometric properties of the abridged Arabic version of the Zarit Burden Interview among caregivers of cancer patients. Eur J Oncol Nurs 2013; 17(5): 657-60.
[8] Jivad N, Masoudi R, Heidari M, Etemadi S, Kheyri S. The effect of family-centered care on the family caregivers' burden of patients with epilepsy. Journal of Clinical Nursing and Midwifery 2018; 4(3)
[9] Carlson JM, Miller PA. Family burden, child disability, and the adjustment of mothers caring for children with epilepsy: Role of social support and coping. Epilepsy Behav 2017; 68: 168-73.
[10] Lau S, Chong MS, Ali N, Chan M, Chua KC, Lim WS. Caregiver burden. Alzheimer Dis Assoc Disord 2015; 29(4): 338-46.
[11] Ghaedi Heidari F, Pahlavanzadeh S, Maghsoudi J, Ghazavi Z. Effect of family education program on depression, anxiety and stress of family caregivers of elderly individuals with dementia. J Nurs Educ 2014; 3(1): 12-20.
[12] Yusuf AJ, Nuhu FT, Olisah VO. Emotional distress among caregivers of patients with epilepsy in Katsina State, Northern Nigeria. Afr J Psychiatry (Johannesbg) 2013; 16(1): 41-4.
[13] Tenforde MW, Billig Rose E, Lindsell CJ, et al. Characteristics of adult outpatients and inpatients with COVID-19—11 academic medical centers, United States, March–May 2020. MMWR Morb Mortal Wkly Rep 2020; 69(26): 841-6.
[14] Garg S. Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019—COVID-NET 2020; 1-30. MMWR Morbidity and mortality weekly report. 2020;69.
[15] Onder G, Rezza G, Brusaferro S. Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy. JAMA 2020; 323(18): 1775-6.
[16] Tenforde MW, Chung J, Smith ER, et al. Influenza vaccine effectiveness in inpatient and outpatient settings in the United States, 2015 - 2018. Clin Infect Dis 2020.ciaa407
[17] Bamari F, Madarshahian F, Barzgar B. Reviews burden of caring caregivers of patients with type II diabetes referred to diabetes clinic in the city of Zabol. J Diabetes Nurs 2016; 4(2): 59-67.
[18] Abbaszadeh A. Correlation of burden of care and spiritual health in family caregivers of cancer patients. J Urmia Nurs Midwifery Fac 2019; 17(4): 292-9.
[19] Miguel I, Moreira A, Freire J. Burden, quality of life and distress of the main caregiver in head and neck, cervix and rectum cancer patients. J Cancer Res Ther 2017; 5(3): 14-8.
[20] Rezaei A. Relationship between general health and burden in female caregivers of patients with Alzheimer disease 2015.
[21] Rha SY, Park Y, Song SK, Lee CE, Lee J. Caregiving burden and the quality of life of family caregivers of cancer patients: The relationship and correlates. Eur J Oncol Nurs 2015; 19(4): 376-82.
[22] Osse BH, Vernooij-Dassen MJ, Schadé E, Grol RP. Problems experienced by the informal caregivers of cancer patients and their needs for support. Cancer Nurs 2006; 29(5): 378-88.
[23] Yun YH, Lee MK, Chang YJ, et al. The life-sustaining treatments among cancer patients at end of life and the caregiver’s experience and perspectives. Support Care Cancer 2010; 18(2): 189-96.
[24] Grunfeld E, Coyle D, Whelan T, et al. Family caregiver burden: Results of a longitudinal study of breast cancer patients and their principal caregivers. CMAJ 2004; 170(12): 1795-801.
[25] Farnoosh G, Alishiri G, Hosseini Zijoud SR, Dorostkar R, Jalali Farahani A. Understanding the severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] and coronavirus disease [COVID-19] based on available evidence-a narrative review. J Mil Med 2020; 22(1): 1-11.
[26] Bradley CJ, Dahman B. Time away from work: employed husbands of women treated for breast cancer. J Cancer Surviv 2013; 7(2): 227-36.
[27] Kim Y, Kashy DA, Spillers RL, Evans TV. Needs assessment of family caregivers of cancer survivors: three cohorts comparison. Psycho Oncology. J Psychol Soci Behavi Dimens Cancer 2010; 19(6): 573-82.